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Synopsis
miRVaS is a program designed to predict the impact of genetic variants on miRNAs.
Main features
- Annotates the location of the variant relative to functional regions within the miRNA
- Predicts the structural impact of the variant on the miRNA, and annotates the locations of structural change in the miRNA.
- Creates structure drawings of both wild type and variant with miRNA functional regions highlighted for comparison
Use
You can either
download the program and use locally, or you
can
analyse your variant data online
News
- 2015-07-17 Online analysis is available, as well as a version 1.0.1 (with some small fixes)
- 2015-03-10 First version is available.
Citation
You can freely use the program, but if you publish results obtained with the help of miRVaS,
it should be cited (manuscript currently in preparation):
- miRVaS: a tool to predict the impact of genetic variants on miRNAs (in preparation).
Sophia Cammaerts, Mojca Strazisar, Jenne Dierckx, Jurgen Del-Favero, Peter De Rijk
Since with miRVaS you are also using the underlying tools RNAfold and VARNA, these should be cited as well.
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Lorenz, R., Bernhart, S.H., Höner Zu Siederdissen, C., Tafer, H., Flamm, C., Stadler, P.F., Hofacker, I.L., (2011).
ViennaRNA Package 2.0. Algorithms Mol Biol 6, 26. doi:10.1186/1748-7188-6-26
(pubmed: 22115189)
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Darty, K., Denise, A., Ponty, Y. (2009).
VARNA: Interactive drawing and editing of the RNA secondary structure. Bioinformatics 25, 1974\u20131975. doi:10.1093/bioinformatics/btp250
(pubmed: 19398448)
